page_banner

nhau

news

Kutevedzera physiological mamiriro kunobatsira vatsvakurudzi kuwana simbi binders

Vatsvagiri vakagadzira nzira yekuziva mamorekuru madiki anosunga simbi ions.Metal ions yakakosha mubiology.Asi kuziva kuti mamorekuru ndeapi - uye kunyanya mamorekuru madiki - iwo maion esimbi anodyidzana nawo anogona kuve akaoma.

Kuparadzanisa mametabolites ekuongororwa, nzira dzakajairwa dzemetabolomics dzinoshandisa organic solvents uye yakaderera pHs, izvo zvinogona kukonzera simbi yakaoma kuti iparadzane.Pieter C. Dorrestein weUniversity of California San Diego nevamwe vaaishanda navo vaida kuchengeta macomplexes pamwe chete kuti aongororwe nekutevedzera mamiriro anowanikwa mumaseru.Asi kana vakashandisa physiological mamiriro panguva yekuparadzaniswa kwemamorekuru, vangadai vakafanirwa kugadzirisa zvakare mamiriro ekuparadzanisa kune yega yega mamiriro emuviri wavaida kuyedza.

Pane kudaro, vatsvakurudzi vakagadzira nzira mbiri-nhanho iyo inotanga mamiriro ehupenyu pakati pezvakajairwa chromatographic separation uye mass spectrometric analysis (Nat. Chem. 2021, DOI: 10.1038 / s41557-021-00803-1).Chekutanga, vakapatsanura chidimbu chebiological vachishandisa yakajairika yepamusoro-inoshanda liquid chromatography.Vakabva vagadzirisa pH yekuyerera ichibuda mukoramu yechromatographic kuti vatevedzere mamiriro emuviri, vakawedzera simbi ions, uye vakaongorora musanganiswa nehukuru spectrometry.Vakamhanyisa ongororo kaviri kuti vawane misa spectra yemamorekuru madiki ane uye asina simbi.Kuti vaone kuti ndeapi mamorekuru anosunga simbi, vakashandisa nzira yekombuta inoshandisa maumbirwo epamusoro-soro kuti vape hukama pakati pemhando yemhando dzakasungwa uye dzisina kusungwa.

Imwe nzira yekuwedzera kutevedzera mamiriro emuviri, Dorrestein anoti, ingave yekuwedzera yakanyanya kuwanda kweiyoni yakadai sesodium kana potasium uye kudzika kwakadzika kwesimbi yekufarira.“Zvinova kuedza kwemakwikwi.Ichanyatso kukuudza, zvakanaka, iyi morekuru pasi peaya mamiriro ane hunyanzvi hwekusunga sodium nepotassium kana iyi simbi yakasarudzika yawakawedzera, ”anodaro Dorrestein."Tinogona kupinza simbi dzakasiyana siyana panguva imwe chete, uye isu tinogona kunyatsonzwisisa zvatinoda uye kusarudza mumamiriro ezvinhu aya."

Muzvinyorwa zvetsika kubva kuEscherichia coli, vatsvakurudzi vakaona anozivikanwa iron-binding compounds seyersiniabactin uye aerobactin.Kana iri yersiniabactin, vakawana kuti inogona zvakare kusunga zinc.

Vatsvakurudzi vakacherechedza simbi-inosunga makomisheni mumasampuli akaoma seyakanyungudika organic zvinhu kubva munyanza."Ndiyo imwe yemuenzaniso wakaoma kwazvo wandati ndambotarisa," Dorrestein anodaro."Zvichida zvakaoma se, kana zvisina kuoma kupfuura, crude oil."Iyo nzira yakaratidza domoic acid semhangura-inosunga morekuru uye yakataura kuti inosunga Cu2+ sedhiri.

"Maitiro ekuona mametabolites anosunga simbi mumuenzaniso anobatsira zvakanyanya nekuda kwekukosha kwebiological metal chelation," Oliver Baars, anodzidza metabolites inosunga simbi inogadzirwa nezvirimwa uye tupukanana paNorth Carolina State University, anonyora mu email.

"Dorrestein nevaanoshanda navo vanopa yakanakisa, inodiwa, kuyedza kuongorora zvirinani kuti basa remuviri remaoni esimbi muchitokisi ringave rini," Albert JR Heck, piyona muongororo yeruzhinji yeruzhinji paUtrecht University, anonyora mune email."Chinogoneka chinotevera nhanho chingave chekubvisa mametabolites pasi pemamiriro ekunze kubva muchitokisi uye kupatsanura aya zvakare pasi pemamiriro ekunze, kuona kuti ndeapi metabolites anotakura ayo endogenous cellular metal ions."

Chemical & Engineering Nhau
ISSN 0009-2347
Copyright © 2021 American Chemical Society


Nguva yekutumira: Zvita-23-2021